The VirSR two - component signal transduction system regulates NetB 3 toxin production in Clostridium perfringens 4 5 6 7 8
نویسندگان
چکیده
منابع مشابه
Regulation of Sialidase Production in Clostridium perfringens by the Orphan Sensor Histidine Kinase ReeS
Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract. It is the primary etiological agent of clostridial myonecrosis, or gas gangrene, a serious infection that results in extensive tissue necrosis due to the action of one or more potent extracellular toxins. α-toxin and perfringolysin O are the major extracellular toxin...
متن کاملNanI Sialidase , CcpA and CodY Work Together to Regulate Epsilon Toxin 1 Production by Clostridium perfringens Type D Strain CN 3718
NanI Sialidase, CcpA and CodY Work Together to Regulate Epsilon Toxin 1 Production by Clostridium perfringens Type D Strain CN3718 2 3 Jihong Li, John C. Freedman and Bruce A. McClane* 4 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of 5 Medicine, Pittsburgh, PA, USA 15219 6 7 8 Running title: C. perfringens NanI regulates ETX production 9
متن کاملFunctional Analysis of the VirSR Phosphorelay from Clostridium perfringens
Toxin production in Clostridium perfringens is controlled by the VirSR two-component signal transduction system, which comprises the VirS sensor histidine kinase and the VirR response regulator. Other studies have concentrated on the elucidation of the genes controlled by this network; there is little information regarding the phosphorelay cascade that is the hallmark of such regulatory systems...
متن کاملIn vitro production of necrotic enteritis toxin B, NetB, by netB-positive and netB-negative Clostridium perfringens originating from healthy and diseased broiler chickens.
The Clostridium perfringens necrotic enteritis toxin B, NetB, was recently proposed as a new key virulence factor for the development of necrotic enteritis (NE) in broilers. The aim of the present study was to investigate the presence of the netB gene and the in vitro production of the NetB toxin in a well characterized collection of 48 C. perfringens Type A isolates, obtained from Danish broil...
متن کاملSequence of Two Plasmids from Clostridium perfringens Chicken Necrotic Enteritis Isolates and Comparison with C. perfringens Conjugative Plasmids
Twenty-six isolates of Clostridium perfringens of different MLST types from chickens with necrotic enteritis (NE) (15 netB-positive) or from healthy chickens (6 netB-positive, 5 netB-negative) were found to contain 1-4 large plasmids, with most netB-positive isolates containing 3 large and variably sized plasmids which were more numerous and larger than plasmids in netB-negative isolates. NetB ...
متن کامل